Three independent proliferation and apoptosis assays were performed utilizing carboxyfluorescein succinimidyl ester and Annexin V/PI staining, respectively. ![]() ![]() PANC-1 was induced with increased VPA doses and time points. We aimed to calculate IC 50 of VPA-induced PANC-1 cells by combined analyses of proliferation and apoptosis, while assessing its effect on Wnt signaling pathway. However, VPA-induced apoptosis and its impact on Wnt signaling in PDACs are not linked, yet. Wnt signaling pathway is known to be involved in apoptosis and PDAC onset. Valproic acid (VPA) was shown to induce apoptosis and reduce proliferation in PANC-1 cells. Since most patients develop resistance to conventional treatments, new approaches are in urgency. ![]() Pancreatic ductal adenocarcinoma (PDAC) is among the most deadly cancers.
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